| 24. Ronde | 09.08.2021 | Thespakusatsu Gunma | - | Ehime FC | 1:1 | ||||
| 25. Ronde | 15.08.2021 | Ehime FC | - | Giravanz Kitakyushu | 2:2 | ||||
| 26. Ronde | 22.08.2021 | Matsumoto Yamaga | - | Ehime FC | 0:1 | ||||
| 27. Ronde | 29.08.2021 | Ehime FC | - | Tochigi SC | 0:1 | ||||
| 28. Ronde | 05.09.2021 | Fagiano Okayama | - | Ehime FC | 0:0 | ||||
| 29. Ronde | 12.09.2021 | Ehime FC | - | RB Omiya Ardija | 3:3 | ||||
| 30. Ronde | 18.09.2021 | JEF United Chiba | - | Ehime FC | 1:0 | ||||
| 32. Ronde | 02.10.2021 | Blaublitz Akita | - | Ehime FC | 0:2 | ||||
| 33. Ronde | 10.10.2021 | Ehime FC | - | V-Varen Nagasaki | 0:2 | ||||
| 34. Ronde | 16.10.2021 | FC Ryūkyū | - | Ehime FC | 0:1 | ||||
| 35. Ronde | 23.10.2021 | Júbilo Iwata | - | Ehime FC | 2:2 | ||||
| 36. Ronde | 30.10.2021 | Ehime FC | - | Kyoto Sanga FC | 0:1 | ||||
| 37. Ronde | 03.11.2021 | Zweigen Kanazawa | - | Ehime FC | 2:1 |  |
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| 38. Ronde | 07.11.2021 | Ehime FC | - | FC Machida Zelvia | 0:0 | ||||
| 39. Ronde | 13.11.2021 | Albirex Niigata | - | Ehime FC | 2:0 | ||||
| 40. Ronde | 21.11.2021 | Ehime FC | - | SC Sagamihara | 1:2 | ||||
| 41. Ronde | 28.11.2021 | Mito HollyHock | - | Ehime FC | 2:1 | ||||
| 42. Ronde | 05.12.2021 | Ehime FC | - | Renofa Yamaguchi | 1:1 |  |
Japan