| 1. Ronde | 11.02.2001 | River Plate | - | Estudiantes | 6:2 |  |
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| 3. Ronde | 17.02.2001 | River Plate | - | Colón de Santa Fe | 3:0 | ||||
| 4. Ronde | 25.02.2001 | Rosario Central | - | River Plate | 1:1 | ||||
| 5. Ronde | 04.03.2001 | River Plate | - | Independiente | 3:1 | ||||
| 6. Ronde | 10.03.2001 | Talleres de Córdoba | - | River Plate | 3:1 | ||||
| 9. Ronde | 01.04.2001 | River Plate | - | Chacarita Juniors | 1:0 | ||||
| 10. Ronde | 08.04.2001 | Boca Juniors | - | River Plate | 3:0 | ||||
| 11. Ronde | 11.04.2001 | River Plate | - | Argentinos Juniors | 3:2 | ||||
| 12. Ronde | 14.04.2001 | Unión de Santa Fe | - | River Plate | 2:3 | ||||
| 14. Ronde | 29.04.2001 | Newell's Old Boys | - | River Plate | 2:3 | ||||
| 15. Ronde | 13.05.2001 | River Plate | - | Racing Club | 3:0 | ||||
| 16. Ronde | 20.05.2001 | Belgrano de Córdoba | - | River Plate | 1:3 | ||||
| 17. Ronde | 27.05.2001 | River Plate | - | Almagro | 5:1 | ||||
| 18. Ronde | 05.06.2001 | Huracán | - | River Plate | 3:2 |
Paraguay