| 1. Ronde | 02.07.2021 | FC Milsami | - | FC Sfîntul Gheorghe | 1:1 | ||||
| 2. Ronde | 18.07.2021 | FC Bălţi | - | FC Milsami | 0:1 | ||||
| 5. Ronde | 08.08.2021 | FC Milsami | - | FC Floreşti | 4:1 | ||||
| 7. Ronde | 21.08.2021 | FC Milsami | - | Dinamo-Auto | 4:1 | ||||
| 9. Ronde | 11.09.2021 | FC Milsami | - | FC Bălţi | 1:1 | ||||
| 10. Ronde | 17.09.2021 | CS Petrocub | - | FC Milsami | 1:1 | ||||
| 12. Ronde | 26.09.2021 | FC Floreşti | - | FC Milsami | 0:3 | ||||
| 13. Ronde | 02.10.2021 | FC Milsami | - | FC Sheriff | 0:1 | ||||
| 14. Ronde | 17.10.2021 | Dinamo-Auto | - | FC Milsami | 1:3 | ||||
| 16. Ronde | 30.10.2021 | FC Bălţi | - | FC Milsami | 0:1 | ||||
| 18. Ronde | 20.11.2021 | FC Zimbru | - | FC Milsami | 1:2 | ||||
| 19. Ronde | 28.11.2021 | FC Milsami | - | FC Floreşti | 5:0 | ||||
| 6. Ronde | 01.03.2022 | FC Sheriff | - | FC Milsami | 1:0 | ||||
| 20. Ronde | 13.03.2022 | FC Sheriff | - | FC Milsami | 0:1 | ||||
| 23. Ronde | 09.04.2022 | FC Milsami | - | FC Bălţi | 0:2 | ||||
| 24. Ronde | 17.04.2022 | CS Petrocub | - | FC Milsami | 1:0 | ||||
| 25. Ronde | 21.04.2022 | FC Milsami | - | FC Zimbru | 3:0 | ||||
| 27. Ronde | 07.05.2022 | FC Milsami | - | FC Sheriff | 1:1 | ||||
| 28. Ronde | 14.05.2022 | Dinamo-Auto | - | FC Milsami | 2:2 |  |
Moldavië
Rusland