| 1. Ronde | 31.08.2016 | Boston River | - | Defensor Sporting | 1:1 | ||||
| 2. Ronde | 04.09.2016 | Defensor Sporting | - | Juventud de Las Piedras | 0:1 | ||||
| 3. Ronde | 11.09.2016 | Defensor Sporting | - | Sud América | 2:0 | ||||
| 4. Ronde | 18.09.2016 | River Plate | - | Defensor Sporting | 0:5 | ||||
| 5. Ronde | 24.09.2016 | Defensor Sporting | - | CA Cerro | 0:1 |  |
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| 6. Ronde | 02.10.2016 | Defensor Sporting | - | Montevideo Wanderers | 1:1 | ||||
| 7. Ronde | 09.10.2016 | Fénix | - | Defensor Sporting | 3:1 | ||||
| 8. Ronde | 16.10.2016 | Defensor Sporting | - | Liverpool | 1:3 | ||||
| 9. Ronde | 23.10.2016 | Plaza Colonia | - | Defensor Sporting | 0:1 | ||||
| 10. Ronde | 29.10.2016 | Rampla Juniors | - | Defensor Sporting | 0:1 | ||||
| 11. Ronde | 12.11.2016 | Villa Española | - | Defensor Sporting | 2:2 | ||||
| 12. Ronde | 20.11.2016 | Defensor Sporting | - | Nacional | 3:2 | ||||
| 13. Ronde | 26.11.2016 | Defensor Sporting | - | Danubio | 0:0 | ||||
| 14. Ronde | 04.12.2016 | Defensor Sporting | - | Racing | 2:1 | ||||
| 15. Ronde | 10.12.2016 | Peñarol | - | Defensor Sporting | 0:2 |  |
Uruguay