| 1. Ronde | 03.06.2021 | Defensor Sporting | - | Rocha | 2:1 | ||||
| 3. Ronde | 16.06.2021 | Albion | - | Defensor Sporting | 2:2 | ||||
| 4. Ronde | 26.06.2021 | Defensor Sporting | - | Central Español | 4:0 | ||||
| 7. Ronde | 15.07.2021 | Villa Teresa | - | Defensor Sporting | 0:2 | ||||
| 8. Ronde | 22.07.2021 | Defensor Sporting | - | Juventud de Las Piedras | 1:2 |  |
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| 9. Ronde | 28.07.2021 | Uruguay Montevideo | - | Defensor Sporting | 0:2 | |
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| 10. Ronde | 05.08.2021 | Defensor Sporting | - | Rampla Juniors | 1:0 | ||||
| 11. Ronde | 14.08.2021 | Danubio | - | Defensor Sporting | 0:1 | ||||
| 12. Ronde | 16.09.2021 | Rocha | - | Defensor Sporting | 1:2 | ||||
| 13. Ronde | 23.09.2021 | Defensor Sporting | - | CA Cerro | 2:0 | ||||
| 14. Ronde | 30.09.2021 | Defensor Sporting | - | Albion | 0:1 | |
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| 15. Ronde | 05.10.2021 | Central Español | - | Defensor Sporting | 1:0 | |
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| 16. Ronde | 12.10.2021 | Defensor Sporting | - | Atenas | 1:1 | ||||
| 17. Ronde | 20.10.2021 | Racing | - | Defensor Sporting | 0:1 | ||||
| 18. Ronde | 29.10.2021 | Defensor Sporting | - | Villa Teresa | 1:2 | ||||
| 19. Ronde | 02.11.2021 | Juventud de Las Piedras | - | Defensor Sporting | 3:3 |
Uruguay