| 1. Ronde | 06.02.2022 | Boston River | - | Plaza Colonia | 0:0 | ||||
| 2. Ronde | 12.02.2022 | Plaza Colonia | - | River Plate | 0:1 |  |
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| 3. Ronde | 19.02.2022 | Cerro Largo | - | Plaza Colonia | 0:5 |  |
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| 5. Ronde | 12.03.2022 | Defensor Sporting | - | Plaza Colonia | 0:0 | ||||
| 6. Ronde | 20.03.2022 | Plaza Colonia | - | Albion | 1:1 | ||||
| 7. Ronde | 02.04.2022 | Nacional | - | Plaza Colonia | 1:0 | ||||
| 8. Ronde | 09.04.2022 | Plaza Colonia | - | Danubio | 1:1 | ||||
| 9. Ronde | 17.04.2022 | Deportivo Maldonado | - | Plaza Colonia | 3:1 |  |
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| 11. Ronde | 07.05.2022 | Liverpool | - | Plaza Colonia | 1:0 | ||||
| 12. Ronde | 14.05.2022 | Plaza Colonia | - | Peñarol | 0:1 | ||||
| 13. Ronde | 24.05.2022 | Montevideo City Torque | - | Plaza Colonia | 1:1 | ||||
| 15. Ronde | 04.06.2022 | Cerrito | - | Plaza Colonia | 1:1 |
Uruguay