| 1. Ronde | 17.01.2021 | Fénix | - | River Plate | 0:3 Toeg. | ||||
| 2. Ronde | 20.01.2021 | River Plate | - | CA Cerro | 1:2 |  |
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| 4. Ronde | 04.02.2021 | River Plate | - | Danubio | 0:4 | ||||
| 5. Ronde | 08.02.2021 | Nacional | - | River Plate | 3:0 | ||||
| 8. Ronde | 17.02.2021 | River Plate | - | Rentistas | 1:1 | ||||
| 9. Ronde | 20.02.2021 | River Plate | - | Cerro Largo | 2:0 | ||||
| 10. Ronde | 27.02.2021 | River Plate | - | Montevideo Wanderers | 1:1 | ||||
| 14. Ronde | 26.03.2021 | Plaza Colonia | - | River Plate | 1:0 | ||||
| 15. Ronde | 29.03.2021 | River Plate | - | Progreso | 3:2 | |
Uruguay