| 1. Ronde | 13.03.2021 | Shakhter Soligorsk | - | FK Minsk | 1:0 | ||||
| 2. Ronde | 20.03.2021 | Energetik-BGU Minsk | - | Shakhter Soligorsk | 1:2 | ||||
| 3. Ronde | 03.04.2021 | Shakhter Soligorsk | - | FK Isloch Minsk | 4:0 | ||||
| 4. Ronde | 11.04.2021 | Shakhter Soligorsk | - | FK Smorgon | 3:0 |  |
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| 5. Ronde | 17.04.2021 | Shakhter Soligorsk | - | FK Slaviya Mozyr | 4:1 | ||||
| 6. Ronde | 25.04.2021 | Shakhter Soligorsk | - | Rukh Brest | 4:1 | ||||
| 12. Ronde | 12.06.2021 | Shakhter Soligorsk | - | FK Vitebsk | 2:0 | ||||
| 13. Ronde | 18.06.2021 | FK Slutsk | - | Shakhter Soligorsk | 1:4 | |
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| 14. Ronde | 26.06.2021 | Shakhter Soligorsk | - | Dinamo Brest | 1:1 | ||||
| 18. Ronde | 02.08.2021 | FK Isloch Minsk | - | Shakhter Soligorsk | 0:1 | ||||
| 19. Ronde | 15.08.2021 | FK Smorgon | - | Shakhter Soligorsk | 2:2 | ||||
| 23. Ronde | 18.09.2021 | BATE Borisov | - | Shakhter Soligorsk | 1:0 | ||||
| 17. Ronde | 22.09.2021 | Shakhter Soligorsk | - | Energetik-BGU Minsk | 2:0 | ||||
| 24. Ronde | 26.09.2021 | Shakhter Soligorsk | - | Neman Grodno | 1:0 | ||||
| 15. Ronde | 27.10.2021 | FK Gomel | - | Shakhter Soligorsk | 2:3 |  |
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| 28. Ronde | 06.11.2021 | Shakhter Soligorsk | - | FK Slutsk | 1:1 |
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