| 2. Ronde | 12.09.2021 | Doxa Katokopias | - | Anorthosis Famagusta | 2:0 | ||||
| 3. Ronde | 20.09.2021 | Anorthosis Famagusta | - | Ethnikos Achna | 2:1 | ||||
| 4. Ronde | 25.09.2021 | Aris Limassol | - | Anorthosis Famagusta | 3:2 |  |
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| 5. Ronde | 03.10.2021 | Anorthosis Famagusta | - | APOEL Nicosia | 2:1 | ||||
| 6. Ronde | 17.10.2021 | AEL Limassol | - | Anorthosis Famagusta | 2:1 | ||||
| 7. Ronde | 25.10.2021 | Anorthosis Famagusta | - | AEK Larnaca | 1:2 | ||||
| 9. Ronde | 07.11.2021 | Anorthosis Famagusta | - | Paphos FC | 1:0 | |
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| 10. Ronde | 20.11.2021 | Olympiakos Nikosia | - | Anorthosis Famagusta | 3:2 | ||||
| 11. Ronde | 29.11.2021 | Anorthosis Famagusta | - | Apollon Limassol | 1:1 | ||||
| 18. Ronde | 24.01.2022 | AEK Larnaca | - | Anorthosis Famagusta | 1:1 | ||||
| 19. Ronde | 29.01.2022 | Anorthosis Famagusta | - | Omonia Nikosia | 1:1 | ||||
| 15. Ronde | 10.02.2022 | Anorthosis Famagusta | - | Aris Limassol | 3:1 | ||||
| 21. Ronde | 14.02.2022 | Anorthosis Famagusta | - | Olympiakos Nikosia | 3:1 | ||||
| 22. Ronde | 26.02.2022 | Apollon Limassol | - | Anorthosis Famagusta | 2:2 |
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