| 7. Ronde | 30.04.2021 | Rukh Brest | - | FK Slaviya Mozyr | 2:1 | ||||
| 8. Ronde | 08.05.2021 | Rukh Brest | - | Sputnik Rechytsa | 2:0 | ||||
| 14. Ronde | 27.06.2021 | Rukh Brest | - | FK Slutsk | 1:0 | ||||
| 16. Ronde | 17.07.2021 | FK Gomel | - | Rukh Brest | 0:0 | ||||
| 17. Ronde | 23.07.2021 | Rukh Brest | - | FK Minsk | 1:0 | ||||
| 18. Ronde | 30.07.2021 | Energetik-BGU Minsk | - | Rukh Brest | 0:2 |  |
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| 19. Ronde | 13.08.2021 | Rukh Brest | - | FK Isloch Minsk | 7:1 | ||||
| 20. Ronde | 21.08.2021 | FK Smorgon | - | Rukh Brest | 1:1 | ||||
| 21. Ronde | 27.08.2021 | Rukh Brest | - | Shakhter Soligorsk | 1:0 | ||||
| 22. Ronde | 12.09.2021 | FK Slaviya Mozyr | - | Rukh Brest | 1:1 |  |
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| 24. Ronde | 25.09.2021 | Rukh Brest | - | BATE Borisov | 2:2 | ||||
| 25. Ronde | 01.10.2021 | Neman Grodno | - | Rukh Brest | 0:1 |  |
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| 27. Ronde | 24.10.2021 | Torpedo-BelAZ Zhodino | - | Rukh Brest | 3:3 | ||||
| 28. Ronde | 05.11.2021 | Rukh Brest | - | FK Vitebsk | 2:0 | |
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| 30. Ronde | 28.11.2021 | Rukh Brest | - | Dinamo Brest | 3:2 | |
Wit-Rusland