| 1. Ronde | 19.07.2021 | Deportes Tolima | - | Deportivo Pereira | 1:0 | ||||
| 8. Ronde | 07.09.2021 | Deportes Tolima | - | Envigado FC | 2:0 |  |
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| 9. Ronde | 14.09.2021 | Atlético Huila | - | Deportes Tolima | 1:2 |  |
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| 11. Ronde | 26.09.2021 | Patriotas FC | - | Deportes Tolima | 0:0 | ||||
| 14. Ronde | 16.10.2021 | Deportes Tolima | - | Atlético Huila | 1:0 | ||||
| 15. Ronde | 24.10.2021 | Independiente Medellín | - | Deportes Tolima | 2:2 | ||||
| 16. Ronde | 29.10.2021 | Deportes Tolima | - | América de Cali | 0:1 | ||||
| 17. Ronde | 03.11.2021 | Águilas Doradas | - | Deportes Tolima | 1:1 | ||||
| 18. Ronde | 08.11.2021 | Deportes Tolima | - | Millonarios | 3:2 | |
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| 19. Ronde | 15.11.2021 | Atlético Bucaramanga | - | Deportes Tolima | 1:1 | ||||
| 20. Ronde | 21.11.2021 | Deportes Tolima | - | Deportes Quindío | 3:1 |
Colombia