| 1. Ronde | 12.08.2021 | Balzan FC | - | Sliema Wanderers | 1:0 | ||||
| 2. Ronde | 20.08.2021 | Sliema Wanderers | - | Floriana FC | 0:0 |  |
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| 3. Ronde | 11.09.2021 | Gżira United | - | Sliema Wanderers | 1:1 | ||||
| 4. Ronde | 19.09.2021 | Sliema Wanderers | - | Gudja United | 2:3 | ||||
| 5. Ronde | 26.09.2021 | Sirens FC | - | Sliema Wanderers | 2:2 |  |
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| 6. Ronde | 17.10.2021 | Sliema Wanderers | - | Hibernians FC | 0:3 | ||||
| 7. Ronde | 24.10.2021 | St. Luċija FC | - | Sliema Wanderers | 0:0 | ||||
| 8. Ronde | 31.10.2021 | Sliema Wanderers | - | Mosta FC | 2:3 | ||||
| 9. Ronde | 20.11.2021 | Sliema Wanderers | - | Valletta FC | 0:3 Toeg. | ||||
| 10. Ronde | 27.11.2021 | Birkirkara FC | - | Sliema Wanderers | 2:0 | ||||
| 11. Ronde | 05.12.2021 | Sliema Wanderers | - | Hamrun Spartans | 0:2 | ||||
| 13. Ronde | 19.12.2021 | Floriana FC | - | Sliema Wanderers | 2:0 | ||||
| 20. Ronde | 26.02.2022 | Valletta FC | - | Sliema Wanderers | 1:0 | ||||
| 21. Ronde | 06.03.2022 | Sliema Wanderers | - | Birkirkara FC | 0:0 | |
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| 22. Ronde | 11.03.2022 | Hamrun Spartans | - | Sliema Wanderers | 3:1 |
Malta