| 1. Ronde | 16.08.2021 | West Ham United U23 | - | Arsenal FC U23 | 6:1 | ||||
| 2. Ronde | 20.08.2021 | Arsenal FC U23 | - | Crystal Palace U23 | 4:2 | ||||
| 3. Ronde | 27.08.2021 | Tottenham Hotspur U23 | - | Arsenal FC U23 | 1:2 | ||||
| 4. Ronde | 11.09.2021 | Arsenal FC U23 | - | Manchester United U23 | 3:1 | ||||
| 5. Ronde | 19.09.2021 | Chelsea FC U23 | - | Arsenal FC U23 | 1:6 |  |
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| 7. Ronde | 01.10.2021 | Arsenal FC U23 | - | Brighton & Hove Albion U23 | 3:0 | ||||
| 8. Ronde | 16.10.2021 | Liverpool FC U23 | - | Arsenal FC U23 | 3:0 |  |
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| 9. Ronde | 22.10.2021 | Arsenal FC U23 | - | Everton FC U23 | 4:0 | ||||
| 10. Ronde | 29.10.2021 | Leeds United U23 | - | Arsenal FC U23 | 2:4 | ||||
| 12. Ronde | 22.11.2021 | Blackburn Rovers U23 | - | Arsenal FC U23 | 2:3 | ||||
| 14. Ronde | 06.12.2021 | Everton FC U23 | - | Arsenal FC U23 | 2:0 | ||||
| 24. Ronde | 04.04.2022 | Arsenal FC U23 | - | Manchester City U23 | 3:3 | ||||
| 25. Ronde | 22.04.2022 | Manchester United U23 | - | Arsenal FC U23 | 1:1 | ||||
| 26. Ronde | 29.04.2022 | Arsenal FC U23 | - | Leeds United U23 | 1:1 |
Nederland