| 5. Ronde | 27.08.2021 | Platense | - | Marathón | 3:1 |  |
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| 6. Ronde | 29.08.2021 | Real Sociedad | - | Platense | 1:1 | ||||
| 7. Ronde | 02.09.2021 | Olimpia | - | Platense | 3:0 | ||||
| 8. Ronde | 13.09.2021 | Platense | - | Vida | 1:4 |  |
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| 11. Ronde | 27.09.2021 | Platense | - | Lobos UPNFM | 2:3 | |
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| 12. Ronde | 03.10.2021 | Honduras Progreso | - | Platense | 4:2 | ||||
| 13. Ronde | 10.10.2021 | Platense | - | Motagua | 2:3 | |
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| 14. Ronde | 17.10.2021 | Real España | - | Platense | 2:1 |
Honduras