| 4. Ronde | 15.08.2021 | Alianza | - | Luis Ángel Firpo | 2:2 | ||||
| 6. Ronde | 26.08.2021 | Alianza | - | FAS | 1:0 | ||||
| 7. Ronde | 29.08.2021 | Isidro Metapán | - | Alianza | 1:2 | ||||
| 5. Ronde | 10.09.2021 | Alianza | - | Once Municipal | 1:0 | ||||
| 8. Ronde | 12.09.2021 | Alianza | - | Atlético Marte | 3:1 | ||||
| 11. Ronde | 25.09.2021 | Jocoro FC | - | Alianza | 3:3 | ||||
| 18. Ronde | 06.11.2021 | Alianza | - | Isidro Metapán | 1:0 | ||||
| 20. Ronde | 18.11.2021 | Alianza | - | Santa Tecla FC | 5:0 |  |
|||
| 22. Ronde | 27.11.2021 | Alianza | - | Jocoro FC | 2:0 |
El Salvador