| 3. Ronde | 15.08.2021 | Lobos UPNFM | - | Honduras Progreso | 3:0 | ||||
| 4. Ronde | 22.08.2021 | Honduras Progreso | - | Victoria | 2:0 | ||||
| 5. Ronde | 26.08.2021 | Olimpia | - | Honduras Progreso | 2:1 | ||||
| 7. Ronde | 05.09.2021 | Honduras Progreso | - | Motagua | 0:3 | ||||
| 10. Ronde | 20.09.2021 | Vida | - | Honduras Progreso | 1:0 | ||||
| 11. Ronde | 23.09.2021 | Victoria | - | Honduras Progreso | 1:2 |
Colombia