| 1. Ronde | 06.02.2021 | 12 de Octubre de Itauguá | - | River Plate | 2:2 | ||||
| 3. Ronde | 15.02.2021 | Sol de América | - | River Plate | 1:1 | ||||
| 6. Ronde | 05.03.2021 | River Plate | - | Guaireña FC | 0:1 | ||||
| 7. Ronde | 10.03.2021 | Cerro Porteño | - | River Plate | 3:0 |  |
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| 9. Ronde | 22.03.2021 | Club Olimpia | - | River Plate | 5:1 | ||||
| 10. Ronde | 02.04.2021 | River Plate | - | 12 de Octubre de Itauguá | 0:2 | ||||
| 11. Ronde | 13.04.2021 | Guaraní | - | River Plate | 2:0 | ||||
| 12. Ronde | 18.04.2021 | River Plate | - | Sol de América | 0:2 | |
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| 13. Ronde | 27.04.2021 | Sportivo Luqueño | - | River Plate | 2:2 | ||||
| 14. Ronde | 04.05.2021 | River Plate | - | Libertad | 1:3 | |
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| 15. Ronde | 10.05.2021 | Guaireña FC | - | River Plate | 0:0 | ||||
| 16. Ronde | 16.05.2021 | River Plate | - | Cerro Porteño | 1:1 | |
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| 17. Ronde | 24.05.2021 | Club Nacional | - | River Plate | 0:1 | ||||
| 18. Ronde | 30.05.2021 | River Plate | - | Club Olimpia | 1:2 |
Paraguay