| 1. Ronde | 16.07.2021 | NK Osijek | - | HNK Šibenik | 3:0 | ||||
| 2. Ronde | 25.07.2021 | Hajduk Split | - | NK Osijek | 1:2 | ||||
| 3. Ronde | 01.08.2021 | NK Osijek | - | Slaven Belupo | 0:0 | ||||
| 4. Ronde | 08.08.2021 | Hrvatski Dragovoljac | - | NK Osijek | 1:2 | ||||
| 5. Ronde | 15.08.2021 | NK Osijek | - | HNK Rijeka | 1:0 | ||||
| 6. Ronde | 22.08.2021 | NK Istra 1961 | - | NK Osijek | 2:0 | ||||
| 8. Ronde | 12.09.2021 | Lokomotiva Zagreb | - | NK Osijek | 1:1 | ||||
| 9. Ronde | 19.09.2021 | NK Osijek | - | HNK Gorica | 3:2 | ||||
| 10. Ronde | 25.09.2021 | HNK Šibenik | - | NK Osijek | 0:2 | ||||
| 11. Ronde | 03.10.2021 | NK Osijek | - | Hajduk Split | 1:1 | ||||
| 12. Ronde | 17.10.2021 | Slaven Belupo | - | NK Osijek | 0:2 |  |
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| 13. Ronde | 23.10.2021 | NK Osijek | - | Hrvatski Dragovoljac | 1:0 | |
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| 15. Ronde | 06.11.2021 | NK Osijek | - | NK Istra 1961 | 3:0 | ||||
| 16. Ronde | 20.11.2021 | Dinamo Zagreb | - | NK Osijek | 1:1 | ||||
| 17. Ronde | 26.11.2021 | NK Osijek | - | Lokomotiva Zagreb | 3:1 | |
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| 14. Ronde | 08.12.2021 | HNK Rijeka | - | NK Osijek | 0:0 | ||||
| 19. Ronde | 12.12.2021 | NK Osijek | - | HNK Šibenik | 3:1 | ||||
| 20. Ronde | 19.12.2021 | Hajduk Split | - | NK Osijek | 0:0 |
Kroatië