| 3. Ronde | 05.09.2021 | FC Istres [A-jun] | - | US Colomiers [A-jun] | 1:1 | ||||
| 4. Ronde | 12.09.2021 | US Colomiers [A-jun] | - | Pieve di Lota [A-jun] | 7:2 |  |
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| 8. Ronde | 10.10.2021 | Nîmes Olympique [A-jun] | - | US Colomiers [A-jun] | 1:0 | ||||
| 9. Ronde | 17.10.2021 | US Colomiers [A-jun] | - | Montpellier HSC [A-jun] | 1:0 | ||||
| 10. Ronde | 24.10.2021 | AS Béziers [A-jun] | - | US Colomiers [A-jun] | 2:1 | ||||
| 12. Ronde | 21.11.2021 | Olympique Marseille [A-jun] | - | US Colomiers [A-jun] | 2:0 | ||||
| 13. Ronde | 28.11.2021 | US Colomiers [A-jun] | - | AS Cannes [A-jun] | 2:1 | ||||
| 14. Ronde | 05.12.2021 | Toulouse FC [A-jun] | - | US Colomiers [A-jun] | 2:0 | ||||
| 25. Ronde | 01.05.2022 | AS Cannes [A-jun] | - | US Colomiers [A-jun] | 0:2 | ||||
| 26. Ronde | 15.05.2022 | US Colomiers [A-jun] | - | OGC Nice [A-jun] | 2:1 |
Frankrijk