| 5. Ronde | 26.09.2021 | AS Muret [B-jun] | - | AC Vedène [B-jun] | 1:1 | ||||
| 11. Ronde | 21.11.2021 | AC Vedène [B-jun] | - | Montauban FC [B-jun] | 3:2 |  |
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| 12. Ronde | 28.11.2021 | Balma SC [B-jun] | - | AC Vedène [B-jun] | 2:1 | ||||
| 13. Ronde | 04.12.2021 | AC Vedène [B-jun] | - | Toulouse FC [B-jun] | 2:4 | ||||
| 14. Ronde | 15.01.2022 | FC Istres [B-jun] | - | AC Vedène [B-jun] | 1:2 | |
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| 15. Ronde | 23.01.2022 | AC Vedène [B-jun] | - | Marignane Gignac [B-jun] | 2:2 | |
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| 16. Ronde | 06.02.2022 | SA Mérignac [B-jun] | - | AC Vedène [B-jun] | 2:0 | ||||
| 17. Ronde | 12.02.2022 | AC Vedène [B-jun] | - | AS Muret [B-jun] | 4:4 | ||||
| 18. Ronde | 06.03.2022 | AC Vedène [B-jun] | - | AS Béziers [B-jun] | 4:3 | ||||
| 19. Ronde | 13.03.2022 | Nîmes Olympique [B-jun] | - | AC Vedène [B-jun] | 3:1 |
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