| 1. Ronde | 03.06.2021 | Defensor Sporting | - | Rocha | 2:1 | ||||
| 2. Ronde | 11.06.2021 | CA Cerro | - | Defensor Sporting | 0:0 | ||||
| 3. Ronde | 16.06.2021 | Albion | - | Defensor Sporting | 2:2 | ||||
| 4. Ronde | 26.06.2021 | Defensor Sporting | - | Central Español | 4:0 | ||||
| 5. Ronde | 01.07.2021 | Atenas | - | Defensor Sporting | 2:0 |  |
|||
| 6. Ronde | 09.07.2021 | Defensor Sporting | - | Racing | 1:4 | ||||
| 13. Ronde | 23.09.2021 | Defensor Sporting | - | CA Cerro | 2:0 | ||||
| 14. Ronde | 30.09.2021 | Defensor Sporting | - | Albion | 0:1 | ||||
| 15. Ronde | 05.10.2021 | Central Español | - | Defensor Sporting | 1:0 | ||||
| 16. Ronde | 12.10.2021 | Defensor Sporting | - | Atenas | 1:1 | |
|||
| 17. Ronde | 20.10.2021 | Racing | - | Defensor Sporting | 0:1 | |
|||
| 18. Ronde | 29.10.2021 | Defensor Sporting | - | Villa Teresa | 1:2 | |
|||
| 21. Ronde | 18.11.2021 | Rampla Juniors | - | Defensor Sporting | 0:5 |
Uruguay