| 1. Ronde | 18.03.2021 | Liga de Portoviejo | - | Guayaquil SC | 1:3 | ||||
| 2. Ronde | 24.03.2021 | Guayaquil SC | - | Cumbayá | 0:1 | ||||
| 3. Ronde | 30.03.2021 | Independiente Juniors | - | Guayaquil SC | 2:3 | ||||
| 4. Ronde | 07.04.2021 | Gualaceo SC | - | Guayaquil SC | 2:0 | ||||
| 7. Ronde | 05.05.2021 | Guayaquil SC | - | Atlético Santo Domingo | 0:1 | ||||
| 8. Ronde | 12.05.2021 | América de Quito | - | Guayaquil SC | 1:2 | ||||
| 9. Ronde | 20.05.2021 | Guayaquil SC | - | Chacaritas FC | 0:0 | ||||
| 10. Ronde | 28.05.2021 | Cumbayá | - | Guayaquil SC | 2:1 | ||||
| 11. Ronde | 02.06.2021 | Guayaquil SC | - | Independiente Juniors | 1:2 | ||||
| 12. Ronde | 06.06.2021 | Guayaquil SC | - | Gualaceo SC | 1:1 | ||||
| 13. Ronde | 11.06.2021 | El Nacional | - | Guayaquil SC | 2:0 | ||||
| 14. Ronde | 13.06.2021 | Guayaquil SC | - | Atlético Porteño | 1:0 |  |
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| 15. Ronde | 16.06.2021 | Atlético Santo Domingo | - | Guayaquil SC | 0:1 | ||||
| 16. Ronde | 20.06.2021 | Guayaquil SC | - | América de Quito | 0:2 | |
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| 17. Ronde | 23.06.2021 | Chacaritas FC | - | Guayaquil SC | 2:3 | ||||
| 18. Ronde | 27.06.2021 | Guayaquil SC | - | Liga de Portoviejo | 2:1 |  |
Ecuador