| 5. Ronde | 29.08.2021 | Juventus Managua | - | H&H Export Sébaco | 1:0 | ||||
| 8. Ronde | 19.09.2021 | Diriangén FC | - | H&H Export Sébaco | 1:0 |  |
|||
| 9. Ronde | 26.09.2021 | Real Madriz | - | H&H Export Sébaco | 3:3 | ||||
| 11. Ronde | 10.10.2021 | H&H Export Sébaco | - | UNAN Managua | 1:1 | ||||
| 12. Ronde | 16.10.2021 | Club Deportivo Ocotal | - | H&H Export Sébaco | 1:1 | ||||
| 13. Ronde | 21.10.2021 | Managua FC | - | H&H Export Sébaco | 1:2 |  |
|||
| 14. Ronde | 23.10.2021 | H&H Export Sébaco | - | Juventus Managua | 3:3 | ||||
| 16. Ronde | 04.11.2021 | H&H Export Sébaco | - | ART Municipal Jalapa | 3:0 | ||||
| 17. Ronde | 17.11.2021 | H&H Export Sébaco | - | Diriangén FC | 1:1 | ||||
| 18. Ronde | 20.11.2021 | H&H Export Sébaco | - | Real Madriz | 2:3 | |
Nicaragua