| 1. Ronde | 01.08.2021 | AD Chalatenango | - | Platense Zacatecoluca | 2:2 |  |
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| 2. Ronde | 08.08.2021 | Platense Zacatecoluca | - | Alianza | 2:2 | ||||
| 3. Ronde | 11.08.2021 | Luis Ángel Firpo | - | Platense Zacatecoluca | 3:2 | |
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| 4. Ronde | 15.08.2021 | Platense Zacatecoluca | - | Once Municipal | 1:1 | ||||
| 5. Ronde | 22.08.2021 | FAS | - | Platense Zacatecoluca | 0:1 | |
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| 6. Ronde | 25.08.2021 | Platense Zacatecoluca | - | Isidro Metapán | 2:1 | |
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| 7. Ronde | 29.08.2021 | Platense Zacatecoluca | - | Atlético Marte | 0:2 |  |
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| 10. Ronde | 19.09.2021 | Platense Zacatecoluca | - | Jocoro FC | 1:1 | ||||
| 11. Ronde | 26.09.2021 | Municipal Limeño | - | Platense Zacatecoluca | 0:1 | ||||
| 12. Ronde | 02.10.2021 | Platense Zacatecoluca | - | AD Chalatenango | 2:1 | ||||
| 14. Ronde | 09.10.2021 | Platense Zacatecoluca | - | Luis Ángel Firpo | 1:3 | ||||
| 13. Ronde | 17.10.2021 | Alianza | - | Platense Zacatecoluca | 4:0 | ||||
| 19. Ronde | 14.11.2021 | Santa Tecla FC | - | Platense Zacatecoluca | 0:1 | ||||
| 20. Ronde | 17.11.2021 | Platense Zacatecoluca | - | CD Águila | 3:2 | ||||
| 21. Ronde | 21.11.2021 | Jocoro FC | - | Platense Zacatecoluca | 1:1 | ||||
| 22. Ronde | 27.11.2021 | Platense Zacatecoluca | - | Municipal Limeño | 0:1 |
El Salvador