| 1. Ronde | 23.01.2022 | Valledupar FC | - | Real Santander | 1:0 | ||||
| 2. Ronde | 30.01.2022 | Real Santander | - | Tigres FC | 0:0 | ||||
| 3. Ronde | 06.02.2022 | Fortaleza FC | - | Real Santander | 2:3 | ||||
| 4. Ronde | 13.02.2022 | Real Santander | - | Barranquilla FC | 2:3 | ||||
| 5. Ronde | 20.02.2022 | Atlético Huila | - | Real Santander | 1:1 | ||||
| 8. Ronde | 10.03.2022 | Atlético FC | - | Real Santander | 0:1 |  |
|||
| 9. Ronde | 21.03.2022 | Real Santander | - | Leones FC | 0:4 | ||||
| 11. Ronde | 03.04.2022 | Real Santander | - | Orsomarso SC | 0:0 | |
|||
| 12. Ronde | 10.04.2022 | Llaneros FC | - | Real Santander | 2:2 | ||||
| 13. Ronde | 16.04.2022 | Real Santander | - | Deportes Quindío | 0:1 |
Colombia