| 6. Ronde | 13.08.2021 | Universidad Técnica | - | Cusco FC | 2:1 |  |
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| 7. Ronde | 17.08.2021 | Cusco FC | - | Mannucci | 2:3 | |
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| 10. Ronde | 11.09.2021 | Ayacucho FC | - | Cusco FC | 1:3 | |
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| 11. Ronde | 17.09.2021 | Cusco FC | - | Alianza Lima | 0:2 | ||||
| 12. Ronde | 22.09.2021 | Sport Boys | - | Cusco FC | 3:2 | |
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| 13. Ronde | 27.09.2021 | Cusco FC | - | Academia Cantolao | 3:2 | ||||
| 14. Ronde | 03.10.2021 | Universidad San Martín | - | Cusco FC | 1:1 | ||||
| 15. Ronde | 18.10.2021 | Cusco FC | - | Deportivo Municipal | 3:5 |
Peru