| 1. Ronde | 02.06.2021 | Albion | - | CA Cerro | 1:2 | ||||
| 2. Ronde | 09.06.2021 | Juventud de Las Piedras | - | Albion | 1:2 |  |
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| 3. Ronde | 16.06.2021 | Albion | - | Defensor Sporting | 2:2 |  |
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| 4. Ronde | 25.06.2021 | Uruguay Montevideo | - | Albion | 2:2 | ||||
| 5. Ronde | 30.06.2021 | Albion | - | Central Español | 1:2 | |
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| 6. Ronde | 08.07.2021 | Rampla Juniors | - | Albion | 0:1 | |
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| 7. Ronde | 15.07.2021 | Albion | - | Atenas | 1:0 | ||||
| 8. Ronde | 22.07.2021 | Danubio | - | Albion | 0:2 | ||||
| 9. Ronde | 29.07.2021 | Albion | - | Racing | 0:0 | ||||
| 10. Ronde | 04.08.2021 | Rocha | - | Albion | 0:2 | |
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| 12. Ronde | 17.09.2021 | CA Cerro | - | Albion | 1:0 | ||||
| 13. Ronde | 22.09.2021 | Albion | - | Juventud de Las Piedras | 1:0 | ||||
| 14. Ronde | 30.09.2021 | Defensor Sporting | - | Albion | 0:1 | |
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| 15. Ronde | 04.10.2021 | Albion | - | Uruguay Montevideo | 1:0 |  |
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| 17. Ronde | 19.10.2021 | Albion | - | Rampla Juniors | 2:0 | ||||
| 18. Ronde | 28.10.2021 | Atenas | - | Albion | 1:2 | |
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| 19. Ronde | 01.11.2021 | Albion | - | Danubio | 2:1 | |
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| 20. Ronde | 09.11.2021 | Racing | - | Albion | 1:1 |  |
Uruguay