| 1. Ronde | 01.08.2021 | Once Municipal | - | CD Águila | 2:2 |  |
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| 2. Ronde | 08.08.2021 | CD Águila | - | FAS | 1:1 | ||||
| 3. Ronde | 12.08.2021 | Isidro Metapán | - | CD Águila | 2:2 | ||||
| 5. Ronde | 22.08.2021 | Santa Tecla FC | - | CD Águila | 2:3 | ||||
| 6. Ronde | 26.08.2021 | CD Águila | - | AD Chalatenango | 2:1 | ||||
| 7. Ronde | 29.08.2021 | CD Águila | - | Jocoro FC | 2:2 | ||||
| 9. Ronde | 16.09.2021 | CD Águila | - | Platense Zacatecoluca | 1:0 | |
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| 11. Ronde | 26.09.2021 | CD Águila | - | Luis Ángel Firpo | 1:1 | ||||
| 12. Ronde | 03.10.2021 | CD Águila | - | Once Municipal | 1:2 |  |
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| 13. Ronde | 18.10.2021 | FAS | - | CD Águila | 0:1 | ||||
| 14. Ronde | 21.10.2021 | CD Águila | - | Isidro Metapán | 4:0 | |
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| 15. Ronde | 24.10.2021 | Atlético Marte | - | CD Águila | 1:2 | ||||
| 16. Ronde | 31.10.2021 | CD Águila | - | Santa Tecla FC | 2:0 | |
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| 17. Ronde | 03.11.2021 | AD Chalatenango | - | CD Águila | 1:1 | ||||
| 18. Ronde | 06.11.2021 | Jocoro FC | - | CD Águila | 2:2 | |
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| 19. Ronde | 14.11.2021 | CD Águila | - | Municipal Limeño | 2:1 | ||||
| 20. Ronde | 17.11.2021 | Platense Zacatecoluca | - | CD Águila | 3:2 | |
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| 21. Ronde | 21.11.2021 | CD Águila | - | Alianza | 0:1 | ||||
| 22. Ronde | 27.11.2021 | Luis Ángel Firpo | - | CD Águila | 1:0 |
El Salvador