| 20. Ronde | 27.02.2021 | Southampton FC U23 | - | Manchester United U23 | 1:2 | ||||
| 14. Ronde | 05.03.2021 | Southampton FC U23 | - | Arsenal FC U23 | 2:2 | ||||
| 18. Ronde | 08.03.2021 | Blackburn Rovers U23 | - | Southampton FC U23 | 5:1 | ||||
| 23. Ronde | 09.04.2021 | Brighton & Hove Albion U23 | - | Southampton FC U23 | 3:0 | ||||
| 13. Ronde | 07.05.2021 | Everton FC U23 | - | Southampton FC U23 | 4:0 |
Ierland