| 1. Ronde | 03.06.2021 | Defensor Sporting | - | Rocha | 2:1 | ||||
| 2. Ronde | 11.06.2021 | CA Cerro | - | Defensor Sporting | 0:0 | ||||
| 3. Ronde | 16.06.2021 | Albion | - | Defensor Sporting | 2:2 | ||||
| 4. Ronde | 26.06.2021 | Defensor Sporting | - | Central Español | 4:0 |  |
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| 5. Ronde | 01.07.2021 | Atenas | - | Defensor Sporting | 2:0 | ||||
| 6. Ronde | 09.07.2021 | Defensor Sporting | - | Racing | 1:4 | ||||
| 7. Ronde | 15.07.2021 | Villa Teresa | - | Defensor Sporting | 0:2 | ||||
| 12. Ronde | 16.09.2021 | Rocha | - | Defensor Sporting | 1:2 | ||||
| 16. Ronde | 12.10.2021 | Defensor Sporting | - | Atenas | 1:1 | ||||
| 17. Ronde | 20.10.2021 | Racing | - | Defensor Sporting | 0:1 | ||||
| 18. Ronde | 29.10.2021 | Defensor Sporting | - | Villa Teresa | 1:2 |  |
Uruguay