| 1. Ronde | 28.07.2021 | Real Cartagena | - | Valledupar FC | 2:2 |  |
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| 4. Ronde | 14.08.2021 | Real Santander | - | Real Cartagena | 2:2 | ||||
| 5. Ronde | 25.08.2021 | Real Cartagena | - | Cortuluá | 2:0 |  |
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| 6. Ronde | 31.08.2021 | Unión Magdalena | - | Real Cartagena | 1:0 | ||||
| 7. Ronde | 04.09.2021 | Real Cartagena | - | Boca Juniors de Cali | 2:0 | ||||
| 9. Ronde | 19.09.2021 | Leones FC | - | Real Cartagena | 2:0 | ||||
| 10. Ronde | 29.09.2021 | Real Cartagena | - | Llaneros FC | 2:1 | ||||
| 11. Ronde | 06.10.2021 | Tigres FC | - | Real Cartagena | 1:2 | |
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| 12. Ronde | 12.10.2021 | Real Cartagena | - | Barranquilla FC | 3:1 | ||||
| 13. Ronde | 20.10.2021 | Bogotá FC | - | Real Cartagena | 0:0 | |
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| 14. Ronde | 26.10.2021 | Real Cartagena | - | Atlético FC | 1:1 | ||||
| 15. Ronde | 30.10.2021 | Orsomarso SC | - | Real Cartagena | 1:1 | |
Colombia