| 11. Ronde | 17.09.2021 | Santos de Guápiles | - | Guadalupe | 2:2 | ||||
| 12. Ronde | 19.09.2021 | Guadalupe | - | CS Herediano | 0:2 | ||||
| 15. Ronde | 15.10.2021 | Deportivo Saprissa | - | Guadalupe | 4:0 | ||||
| 19. Ronde | 30.10.2021 | Guadalupe | - | Jicaral | 2:0 | ||||
| 20. Ronde | 21.11.2021 | Municipal Grecia | - | Guadalupe | 0:0 | ||||
| 21. Ronde | 25.11.2021 | LD Alajuelense | - | Guadalupe | 1:0 |  |
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| 22. Ronde | 28.11.2021 | Guadalupe | - | Santos de Guápiles | 0:5 |
Costa Rica