| 10. Ronde | 12.09.2021 | AD Guanacasteca | - | Jicaral | 1:1 |  |
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| 11. Ronde | 17.09.2021 | Deportivo Saprissa | - | AD Guanacasteca | 1:1 | ||||
| 12. Ronde | 20.09.2021 | AD Guanacasteca | - | Sporting FC | 1:0 | ||||
| 13. Ronde | 25.09.2021 | AD Guanacasteca | - | CS Cartaginés | 2:1 | ||||
| 15. Ronde | 13.10.2021 | Municipal Grecia | - | AD Guanacasteca | 3:1 | ||||
| 16. Ronde | 17.10.2021 | AD Guanacasteca | - | Santos de Guápiles | 1:3 | ||||
| 17. Ronde | 24.10.2021 | LD Alajuelense | - | AD Guanacasteca | 4:1 | ||||
| 18. Ronde | 28.10.2021 | Municipal Pérez Zeledón | - | AD Guanacasteca | 2:0 | ||||
| 20. Ronde | 22.11.2021 | CS Herediano | - | AD Guanacasteca | 5:0 | ||||
| 21. Ronde | 24.11.2021 | Jicaral | - | AD Guanacasteca | 2:2 | ||||
| 22. Ronde | 28.11.2021 | AD Guanacasteca | - | Deportivo Saprissa | 1:0 |
Costa Rica