| 3. Ronde | 23.01.2022 | LD Alajuelense | - | AD Guanacasteca | 4:0 | ||||
| 5. Ronde | 09.02.2022 | AD Guanacasteca | - | Municipal Pérez Zeledón | 0:0 | ||||
| 6. Ronde | 15.02.2022 | AD San Carlos | - | AD Guanacasteca | 3:1 | ||||
| 7. Ronde | 20.02.2022 | AD Guanacasteca | - | Sporting FC | 2:0 |  |
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| 2. Ronde | 23.02.2022 | Jicaral | - | AD Guanacasteca | 2:2 | ||||
| 9. Ronde | 03.03.2022 | Santos de Guápiles | - | AD Guanacasteca | 2:0 | ||||
| 10. Ronde | 06.03.2022 | AD Guanacasteca | - | CS Cartaginés | 1:1 | ||||
| 1. Ronde | 13.03.2022 | AD Guanacasteca | - | Deportivo Saprissa | 1:2 | ||||
| 11. Ronde | 01.04.2022 | AD Guanacasteca | - | Guadalupe | 1:2 | ||||
| 12. Ronde | 07.04.2022 | Deportivo Saprissa | - | AD Guanacasteca | 2:2 | ||||
| 14. Ronde | 16.04.2022 | AD Guanacasteca | - | LD Alajuelense | 0:3 | ||||
| 19. Ronde | 04.05.2022 | AD Guanacasteca | - | CS Herediano | 0:1 | ||||
| 20. Ronde | 07.05.2022 | AD Guanacasteca | - | Santos de Guápiles | 2:0 | ||||
| 21. Ronde | 12.05.2022 | CS Cartaginés | - | AD Guanacasteca | 3:0 | ||||
| 22. Ronde | 15.05.2022 | Guadalupe | - | AD Guanacasteca | 0:0 |
Costa Rica