| 16. Ronde | 23.01.2022 | Pieve di Lota [A-jun] | - | US Colomiers [A-jun] | 0:3 |  |
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| 15. Ronde | 30.01.2022 | US Colomiers [A-jun] | - | FC Istres [A-jun] | 1:0 | ||||
| 17. Ronde | 06.02.2022 | US Colomiers [A-jun] | - | AS Monaco [A-jun] | 1:1 | |
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| 18. Ronde | 13.02.2022 | US Colomiers [A-jun] | - | AS Saint-Étienne [A-jun] | 0:0 | ||||
| 19. Ronde | 06.03.2022 | AC Ajaccio [A-jun] | - | US Colomiers [A-jun] | 3:0 | ||||
| 20. Ronde | 20.03.2022 | US Colomiers [A-jun] | - | Nîmes Olympique [A-jun] | 2:0 | ||||
| 21. Ronde | 27.03.2022 | Montpellier HSC [A-jun] | - | US Colomiers [A-jun] | 0:0 | ||||
| 22. Ronde | 03.04.2022 | US Colomiers [A-jun] | - | AS Béziers [A-jun] | 0:0 | ||||
| 23. Ronde | 10.04.2022 | SC Toulon [A-jun] | - | US Colomiers [A-jun] | 1:1 | ||||
| 24. Ronde | 17.04.2022 | US Colomiers [A-jun] | - | Olympique Marseille [A-jun] | 1:1 | ||||
| 25. Ronde | 01.05.2022 | AS Cannes [A-jun] | - | US Colomiers [A-jun] | 0:2 | |
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| 26. Ronde | 15.05.2022 | US Colomiers [A-jun] | - | OGC Nice [A-jun] | 2:1 | |
Frankrijk