| 1. Ronde | 20.08.2021 | Mamelodi Sundowns | - | AmaZulu FC | 1:0 | ||||
| 4. Ronde | 19.09.2021 | Mamelodi Sundowns | - | TS Galaxy | 3:0 | ||||
| 7. Ronde | 20.10.2021 | Golden Arrows | - | Mamelodi Sundowns | 0:1 | ||||
| 10. Ronde | 07.11.2021 | Marumo Gallants | - | Mamelodi Sundowns | 0:4 | ||||
| 14. Ronde | 08.12.2021 | Mamelodi Sundowns | - | Royal AM | 3:2 | ||||
| 15. Ronde | 11.12.2021 | SuperSport United | - | Mamelodi Sundowns | 0:1 |  |
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| 22. Ronde | 14.12.2021 | Mamelodi Sundowns | - | Baroka FC | 2:1 | ||||
| 16. Ronde | 17.12.2021 | Mamelodi Sundowns | - | Orlando Pirates | 4:1 | ||||
| 17. Ronde | 20.12.2021 | AmaZulu FC | - | Mamelodi Sundowns | 1:0 | ||||
| 23. Ronde | 23.12.2021 | Mamelodi Sundowns | - | Marumo Gallants | 1:1 | ||||
| 20. Ronde | 02.03.2022 | TS Galaxy | - | Mamelodi Sundowns | 0:3 | ||||
| 21. Ronde | 05.03.2022 | Maritzburg United | - | Mamelodi Sundowns | 2:1 | |
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| 26. Ronde | 27.04.2022 | Mamelodi Sundowns | - | Cape Town City FC | 0:0 | ||||
| 27. Ronde | 03.05.2022 | Sekhukhune United | - | Mamelodi Sundowns | 0:2 | ||||
| 28. Ronde | 08.05.2022 | Kaizer Chiefs | - | Mamelodi Sundowns | 1:1 | |
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| 29. Ronde | 14.05.2022 | Mamelodi Sundowns | - | Stellenbosch FC | 0:3 | ||||
| 30. Ronde | 23.05.2022 | Royal AM | - | Mamelodi Sundowns | 2:3 |
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