| 5. Ronde | 02.10.2021 | NEC Nijmegen [U21] | - | sc Heerenveen [U21] | 2:1 | ||||
| 8. Ronde | 30.10.2021 | sc Heerenveen [U21] | - | NEC Nijmegen [U21] | 0:3 | ||||
| 10. Ronde | 20.11.2021 | sc Heerenveen [U21] | - | Almere City FC [U21] | 2:4 | ||||
| 11. Ronde | 27.11.2021 | NAC Breda [U21] | - | sc Heerenveen [U21] | 2:3 |  |
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| 9. Ronde | 30.11.2021 | FC Groningen [U21] | - | sc Heerenveen [U21] | 3:2 | ||||
| 14. Ronde | 04.02.2022 | sc Heerenveen [U21] | - | Feyenoord [U21] | 2:2 | ||||
| 12. Ronde | 12.02.2022 | sc Heerenveen [U21] | - | ADO Den Haag [U21] | 1:1 | ||||
| 13. Ronde | 26.02.2022 | Twente/Heracles [U21] | - | sc Heerenveen [U21] | 1:1 |
Bulgarije