| 2. Ronde | 19.03.2022 | sc Heerenveen [U21] | - | De Graafschap [U21] | 2:1 | ||||
| 3. Ronde | 02.04.2022 | FC Emmen [U21] | - | sc Heerenveen [U21] | 3:2 | ||||
| 5. Ronde | 23.04.2022 | sc Heerenveen [U21] | - | FC Den Bosch [U21] | 1:4 | ||||
| 6. Ronde | 07.05.2022 | Vitesse [U21] | - | sc Heerenveen [U21] | 5:1 | ||||
| 7. Ronde | 13.05.2022 | sc Heerenveen [U21] | - | Twente/Heracles [U21] | 1:4 |
Nederland