| 3. Ronde | 09.04.2021 | Treaty United | - | Cobh Ramblers | 1:1 | ||||
| 13. Ronde | 26.06.2021 | Cobh Ramblers | - | Wexford FC | 3:2 |  |
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| 14. Ronde | 02.07.2021 | Bray Wanderers | - | Cobh Ramblers | 2:1 | ||||
| 15. Ronde | 09.07.2021 | Galway United | - | Cobh Ramblers | 2:0 | ||||
| 16. Ronde | 17.07.2021 | Cobh Ramblers | - | Cabinteely FC | 1:0 | ||||
| 20. Ronde | 21.08.2021 | Cobh Ramblers | - | UC Dublin | 0:2 | ||||
| 21. Ronde | 03.09.2021 | Treaty United | - | Cobh Ramblers | 3:0 | ||||
| 22. Ronde | 10.09.2021 | Wexford FC | - | Cobh Ramblers | 3:1 | ||||
| 23. Ronde | 25.09.2021 | Cobh Ramblers | - | Bray Wanderers | 1:2 | ||||
| 24. Ronde | 01.10.2021 | Cobh Ramblers | - | Galway United | 0:1 | ||||
| 25. Ronde | 08.10.2021 | Cabinteely FC | - | Cobh Ramblers | 1:2 | ||||
| 26. Ronde | 15.10.2021 | Cobh Ramblers | - | Shelbourne FC | 2:0 | ||||
| 27. Ronde | 29.10.2021 | Athlone Town | - | Cobh Ramblers | 1:2 |
Ierland