| 7. Ronde | 06.09.2021 | Atlético FC | - | Valledupar FC | 3:2 | ||||
| 8. Ronde | 11.09.2021 | Valledupar FC | - | Orsomarso SC | 1:2 | ||||
| 10. Ronde | 28.09.2021 | Boyacá Chicó | - | Valledupar FC | 2:0 | ||||
| 11. Ronde | 03.10.2021 | Valledupar FC | - | Fortaleza FC | 1:1 |  |
|||
| 12. Ronde | 09.10.2021 | Real Santander | - | Valledupar FC | 1:1 | ||||
| 13. Ronde | 19.10.2021 | Valledupar FC | - | Cortuluá | 1:2 | ||||
| 14. Ronde | 24.10.2021 | Unión Magdalena | - | Valledupar FC | 3:1 | ||||
| 15. Ronde | 30.10.2021 | Valledupar FC | - | Boca Juniors de Cali | 2:1 |
Colombia