| 4. Ronde | 15.08.2021 | CD Águila | - | Atlético Marte | 4:1 |  |
|||
| 7. Ronde | 29.08.2021 | CD Águila | - | Jocoro FC | 2:2 | |
|||
| 8. Ronde | 12.09.2021 | Municipal Limeño | - | CD Águila | 1:0 | ||||
| 9. Ronde | 16.09.2021 | CD Águila | - | Platense Zacatecoluca | 1:0 | ||||
| 10. Ronde | 19.09.2021 | Alianza | - | CD Águila | 2:1 | ||||
| 12. Ronde | 03.10.2021 | CD Águila | - | Once Municipal | 1:2 | ||||
| 14. Ronde | 21.10.2021 | CD Águila | - | Isidro Metapán | 4:0 | ||||
| 19. Ronde | 14.11.2021 | CD Águila | - | Municipal Limeño | 2:1 | ||||
| 20. Ronde | 17.11.2021 | Platense Zacatecoluca | - | CD Águila | 3:2 |
El Salvador