| 24. Ronde | 09.08.2021 | Giravanz Kitakyushu | - | FC Ryūkyū | 1:2 | ||||
| 25. Ronde | 14.08.2021 | FC Ryūkyū | - | Mito HollyHock | 0:1 | ||||
| 26. Ronde | 22.08.2021 | Montedio Yamagata | - | FC Ryūkyū | 2:2 | ||||
| 27. Ronde | 28.08.2021 | FC Ryūkyū | - | Blaublitz Akita | 2:1 | ||||
| 28. Ronde | 04.09.2021 | V-Varen Nagasaki | - | FC Ryūkyū | 3:1 | ||||
| 29. Ronde | 11.09.2021 | Kyoto Sanga FC | - | FC Ryūkyū | 2:1 | ||||
| 30. Ronde | 18.09.2021 | FC Ryūkyū | - | Thespakusatsu Gunma | 0:1 | ||||
| 31. Ronde | 25.09.2021 | Júbilo Iwata | - | FC Ryūkyū | 2:0 | ||||
| 32. Ronde | 02.10.2021 | FC Ryūkyū | - | Fagiano Okayama | 1:1 | ||||
| 33. Ronde | 09.10.2021 | Ventforet Kofu | - | FC Ryūkyū | 1:0 | ||||
| 34. Ronde | 16.10.2021 | FC Ryūkyū | - | Ehime FC | 0:1 | ||||
| 35. Ronde | 24.10.2021 | Matsumoto Yamaga | - | FC Ryūkyū | 1:2 |  |
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| 36. Ronde | 30.10.2021 | FC Ryūkyū | - | FC Machida Zelvia | 0:0 | ||||
| 38. Ronde | 07.11.2021 | FC Ryūkyū | - | Zweigen Kanazawa | 2:1 |  |
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| 39. Ronde | 13.11.2021 | FC Ryūkyū | - | JEF United Chiba | 2:2 | |
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| 40. Ronde | 21.11.2021 | Tokyo Verdy | - | FC Ryūkyū | 1:1 | ||||
| 41. Ronde | 28.11.2021 | FC Ryūkyū | - | Albirex Niigata | 1:1 | ||||
| 42. Ronde | 05.12.2021 | Tochigi SC | - | FC Ryūkyū | 1:2 |
Japan