| 1. Ronde | 03.09.2022 | NEC Nijmegen [U21] | - | Vitesse [U21] | 0:2 | ||||
| 2. Ronde | 10.09.2022 | Roda JC Kerkrade [U21] | - | NEC Nijmegen [U21] | 2:3 | ||||
| 3. Ronde | 17.09.2022 | NEC Nijmegen [U21] | - | Go Ahead Eagles [U21] | 2:1 |  |
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| 4. Ronde | 01.10.2022 | NAC Breda [U21] | - | NEC Nijmegen [U21] | 4:2 | ||||
| 5. Ronde | 08.10.2022 | VVV-Venlo [U21] | - | NEC Nijmegen [U21] | 0:3 | |
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| 6. Ronde | 15.10.2022 | NEC Nijmegen [U21] | - | Twente/Heracles [U21] | 0:0 | |
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| 8. Ronde | 29.10.2022 | Vitesse [U21] | - | NEC Nijmegen [U21] | 3:1 | ||||
| 9. Ronde | 05.11.2022 | NEC Nijmegen [U21] | - | Roda JC Kerkrade [U21] | 3:1 | ||||
| 12. Ronde | 26.11.2022 | NEC Nijmegen [U21] | - | VVV-Venlo [U21] | 5:0 |  |
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| 13. Ronde | 06.12.2022 | Twente/Heracles [U21] | - | NEC Nijmegen [U21] | 2:0 | ||||
| 11. Ronde | 10.12.2022 | NEC Nijmegen [U21] | - | NAC Breda [U21] | 3:4 | |
Nederland