| 2. Ronde | 12.09.2021 | Doxa Katokopias | - | Anorthosis Famagusta | 2:0 |  |
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| 5. Ronde | 02.10.2021 | Paphos FC | - | Doxa Katokopias | 1:1 | ||||
| 6. Ronde | 18.10.2021 | Doxa Katokopias | - | Aris Limassol | 1:2 |  |
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| 7. Ronde | 22.10.2021 | Olympiakos Nikosia | - | Doxa Katokopias | 1:0 | ||||
| 8. Ronde | 30.10.2021 | Doxa Katokopias | - | APOEL Nicosia | 2:2 | ||||
| 9. Ronde | 05.11.2021 | Apollon Limassol | - | Doxa Katokopias | 3:0 | ||||
| 10. Ronde | 21.11.2021 | Doxa Katokopias | - | AEL Limassol | 0:0 | ||||
| 11. Ronde | 27.11.2021 | PAEEK | - | Doxa Katokopias | 1:2 | |
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| 12. Ronde | 04.12.2021 | Doxa Katokopias | - | AEK Larnaca | 1:4 | ||||
| 13. Ronde | 13.12.2021 | Anorthosis Famagusta | - | Doxa Katokopias | 2:0 | ||||
| 15. Ronde | 03.01.2022 | Ethnikos Achna | - | Doxa Katokopias | 0:1 | ||||
| 18. Ronde | 23.01.2022 | Doxa Katokopias | - | Olympiakos Nikosia | 0:0 | ||||
| 19. Ronde | 30.01.2022 | APOEL Nicosia | - | Doxa Katokopias | 2:0 |  |
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| 20. Ronde | 07.02.2022 | Doxa Katokopias | - | Apollon Limassol | 0:3 | ||||
| 21. Ronde | 15.02.2022 | AEL Limassol | - | Doxa Katokopias | 3:2 | ||||
| 16. Ronde | 18.02.2022 | Doxa Katokopias | - | Paphos FC | 1:1 | ||||
| 22. Ronde | 27.02.2022 | Doxa Katokopias | - | PAEEK | 1:0 |
Benin