| 3. Ronde | 11.09.2021 | FC Istres [B-jun] | - | Nîmes Olympique [B-jun] | 3:3 | ||||
| 11. Ronde | 21.11.2021 | FC Istres [B-jun] | - | AS Béziers [B-jun] | 2:2 | ||||
| 17. Ronde | 13.02.2022 | Rodez AF [B-jun] | - | FC Istres [B-jun] | 0:1 | ||||
| 16. Ronde | 27.02.2022 | FC Istres [B-jun] | - | Montpellier HSC [B-jun] | 2:3 | ||||
| 18. Ronde | 06.03.2022 | FC Istres [B-jun] | - | Girondins Bordeaux [B-jun] | 3:2 | ||||
| 19. Ronde | 13.03.2022 | Montauban FC [B-jun] | - | FC Istres [B-jun] | 2:3 |  |
Frankrijk