| 1. Ronde | 28.08.2021 | FC Istres [B-jun] | - | AS Muret [B-jun] | 2:0 | ||||
| 2. Ronde | 05.09.2021 | AC Vedène [B-jun] | - | FC Istres [B-jun] | 1:3 | ||||
| 7. Ronde | 10.10.2021 | FC Istres [B-jun] | - | Montauban FC [B-jun] | 4:1 |  |
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| 9. Ronde | 23.10.2021 | FC Istres [B-jun] | - | Toulouse FC [B-jun] | 2:1 | |
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| 10. Ronde | 14.11.2021 | Pau FC [B-jun] | - | FC Istres [B-jun] | 4:5 | ||||
| 11. Ronde | 21.11.2021 | FC Istres [B-jun] | - | AS Béziers [B-jun] | 2:2 | ||||
| 12. Ronde | 27.11.2021 | FC Istres [B-jun] | - | Marignane Gignac [B-jun] | 2:2 | ||||
| 21. Ronde | 27.03.2022 | Toulouse FC [B-jun] | - | FC Istres [B-jun] | 5:0 |
Frankrijk