| 1. Ronde | 14.08.2021 | Mosta FC | - | Birkirkara FC | 0:3 | ||||
| 2. Ronde | 20.08.2021 | Sirens FC | - | Mosta FC | 1:1 | ||||
| 3. Ronde | 11.09.2021 | Mosta FC | - | Hamrun Spartans | 1:2 |  |
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| 4. Ronde | 18.09.2021 | Hibernians FC | - | Mosta FC | 3:2 | ||||
| 5. Ronde | 26.09.2021 | Mosta FC | - | Balzan FC | 2:1 | |
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| 6. Ronde | 17.10.2021 | St. Luċija FC | - | Mosta FC | 2:2 | ||||
| 7. Ronde | 23.10.2021 | Mosta FC | - | Floriana FC | 1:1 | ||||
| 8. Ronde | 31.10.2021 | Sliema Wanderers | - | Mosta FC | 2:3 |  |
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| 12. Ronde | 12.12.2021 | Birkirkara FC | - | Mosta FC | 2:2 | |
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| 13. Ronde | 18.12.2021 | Mosta FC | - | Sirens FC | 2:3 | |
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| 16. Ronde | 29.01.2022 | Balzan FC | - | Mosta FC | 2:3 | ||||
| 17. Ronde | 05.02.2022 | Mosta FC | - | St. Luċija FC | 1:0 | |
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| 18. Ronde | 12.02.2022 | Floriana FC | - | Mosta FC | 2:0 | ||||
| 19. Ronde | 20.02.2022 | Mosta FC | - | Sliema Wanderers | 1:0 | |
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| 20. Ronde | 27.02.2022 | Gżira United | - | Mosta FC | 3:4 | ||||
| 21. Ronde | 05.03.2022 | Mosta FC | - | Valletta FC | 2:2 |  |
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| 22. Ronde | 12.03.2022 | Gudja United | - | Mosta FC | 1:0 |
Malta