| 1. Ronde | 07.08.2021 | CD Feirense [A-jun] | - | FC Porto [A-jun] | 1:4 | ||||
| 2. Ronde | 14.08.2021 | FC Porto [A-jun] | - | FC Famalicão [A-jun] | 2:1 | ||||
| 4. Ronde | 29.08.2021 | FC Porto [A-jun] | - | CD Tondela [A-jun] | 5:0 | ||||
| 5. Ronde | 11.09.2021 | UD Oliveirense [A-jun] | - | FC Porto [A-jun] | 0:4 |  |
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| 6. Ronde | 18.09.2021 | FC Porto [A-jun] | - | Gil Vicente [A-jun] | 1:0 | |
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| 8. Ronde | 02.10.2021 | FC Porto [A-jun] | - | FC Vizela [A-jun] | 3:0 | |
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| 9. Ronde | 16.10.2021 | Paços de Ferreira [A-jun] | - | FC Porto [A-jun] | 2:1 | ||||
| 10. Ronde | 23.10.2021 | Leixões SC [A-jun] | - | FC Porto [A-jun] | 1:2 | |
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| 12. Ronde | 07.11.2021 | FC Porto [A-jun] | - | CD Feirense [A-jun] | 4:0 | |
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| 14. Ronde | 13.11.2021 | FC Porto [A-jun] | - | Rio Ave FC [A-jun] | 4:3 | ||||
| 17. Ronde | 12.12.2021 | Gil Vicente [A-jun] | - | FC Porto [A-jun] | 0:6 | ||||
| 21. Ronde | 22.01.2022 | FC Porto [A-jun] | - | Leixões SC [A-jun] | 4:1 | |
Guinea-Bissau