| 1. Ronde | 01.08.2021 | Alianza | - | Municipal Limeño | 4:1 | ||||
| 4. Ronde | 15.08.2021 | Alianza | - | Luis Ángel Firpo | 2:2 |  |
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| 6. Ronde | 26.08.2021 | Alianza | - | FAS | 1:0 | |
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| 7. Ronde | 29.08.2021 | Isidro Metapán | - | Alianza | 1:2 | ||||
| 5. Ronde | 10.09.2021 | Alianza | - | Once Municipal | 1:0 | ||||
| 8. Ronde | 12.09.2021 | Alianza | - | Atlético Marte | 3:1 | ||||
| 9. Ronde | 16.09.2021 | Santa Tecla FC | - | Alianza | 0:4 | ||||
| 10. Ronde | 19.09.2021 | Alianza | - | CD Águila | 2:1 | ||||
| 13. Ronde | 17.10.2021 | Alianza | - | Platense Zacatecoluca | 4:0 | |
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| 14. Ronde | 21.10.2021 | Alianza | - | AD Chalatenango | 1:0 | ||||
| 15. Ronde | 24.10.2021 | Luis Ángel Firpo | - | Alianza | 2:1 | ||||
| 17. Ronde | 02.11.2021 | FAS | - | Alianza | 0:1 | ||||
| 18. Ronde | 06.11.2021 | Alianza | - | Isidro Metapán | 1:0 |  |
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| 19. Ronde | 13.11.2021 | Atlético Marte | - | Alianza | 2:1 | ||||
| 20. Ronde | 18.11.2021 | Alianza | - | Santa Tecla FC | 5:0 | ||||
| 21. Ronde | 21.11.2021 | CD Águila | - | Alianza | 0:1 | |
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| 22. Ronde | 27.11.2021 | Alianza | - | Jocoro FC | 2:0 |
Colombia