| 5. Ronde | 06.02.2021 | Club Necaxa | - | Cruz Azul | 0:2 | ||||
| 6. Ronde | 18.02.2021 | UANL Tigres | - | Cruz Azul | 0:2 | ||||
| 7. Ronde | 21.02.2021 | Cruz Azul | - | Deportivo Toluca | 3:2 | ||||
| 9. Ronde | 04.03.2021 | Cruz Azul | - | Mazatlán FC | 1:0 | ||||
| 12. Ronde | 21.03.2021 | Cruz Azul | - | Atlas Guadalajara | 3:2 | ||||
| 13. Ronde | 03.04.2021 | FC Juárez | - | Cruz Azul | 0:1 | ||||
| 14. Ronde | 11.04.2021 | Cruz Azul | - | Deportivo Guadalajara | 1:0 | ||||
| 15. Ronde | 18.04.2021 | CF América | - | Cruz Azul | 1:1 | ||||
| 16. Ronde | 25.04.2021 | Cruz Azul | - | Atlético San Luis | 3:2 |
Argentinië